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Monday, May 31, 2010

Reduce headaches caused by migraine with aspirin plus metoclopramide

You can substantially reduce headache caused by migraines within two hours with a single dose of 900-1000mg aspirin, according to researchers. Also vomiting and nausea symptoms are greatly reduced if 900mg of aspirin is taken together with 10mg of metoclopramide.

Researchers compared the differences in response rates for people taking aspirin alone or aspirin plus metoclopramide with those of people taking placebo or another active agent and found that 25% of people who took a single dose of 9000-1000mg aspirin had their headaches reduced from severe or moderate to no pain, compared to those who took the placebo. One in two people had the pain reduced to no worse than mild pain.

Aspirin plus metoclopramide was better at reducing symptoms of vomiting, nausea, photophobia and phenophobia than aspirin alone, although it didn’t produce a greater frequency of pain relief. Aspirin plus metoclopramide had a similar effect to 50mg of sumatriptan, a headache treatment, but a 100mg dose of sumatriptan was slighty better at delivering a pain free response within two hours.

“Aspirin plus metoclopramide will be a reasonable therapy for acute migraine attacks, but for many it will be insufficiently effective,” said the study leader Andrew Moore, who works in Pain Relief and the Department of Anaesthetics at the John Radcliffe Hospital, Oxford, UK.

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